Human Somatic Mutation Assays As Biomarkers of Carcinogenesis
نویسندگان
چکیده
منابع مشابه
Human somatic mutation assays as biomarkers of carcinogenesis.
This paper describes four assays that detect somatic gene mutations in humans: the hypoxanthine-guanine phosphoribosyl transferase assay, the glycophorin A assay, the HLA-A assay, and the sickle cell hemoglobin assay. Somatic gene mutation can be considered a biomarker of carcinogenesis, and assays for somatic mutation may assist epidemiologists in studies that attempt to identify factors assoc...
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A study was undertaken in Drosophila of the mutagenic properties of representatives of the various carcinogenic chemical series: alkylating agents, nitroso compounds, hydro carbons, aromatic amines, and urethan. Mutations arising from direct intramolecular DNA damage, such as point mutations and chromosome breaks leading to viable rear rangements, occurred only with the alkylating agents and th...
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SUMMARY Improved diagnostic methods and medical therapies are necessary for early detection and treatment and an improved prognosis. It is thus vital to both examine and evaluate the role of the various existing proteins as biomarkers in carcinogenesis and to assess the contribution of these proteins in anti-cancer activity, for consideration in therapeutic strategies. It is essential to both e...
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INTRODUCTION/OBJECTIVE Persistent infection with high-risk human papillomavirus (HPV) types is a necessary cause for cervical cancer development. The aim of this study was to evaluate the significance of different molecular markers for cervical carcinogenesis, and to assess their association with cervical intraepithelial neoplasia. MATERIALS AND METHODS 378 cervical samples from women attendi...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1991
ISSN: 0091-6765
DOI: 10.2307/3431307